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KMID : 0381219810130010055
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Journal of RIMSK
1981 Volume.13 No. 1 p.55 ~ p.63
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A Quantitative Study of Protein-Bound-Carbohydrate and Seromucoid in Nasal Secretion
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Abstract
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Although numerous studies were carried out to clarify the chemical nature of the nasal secretion and quantitative variation of IgA contents in the secretion of upper respiratory system in allergic condition, the natures and changes of the nasal mucus have not been fully studied.
The mucus is protein-carbohydrate complex chemically, it is divided as seromucoid and non-seromucoid, which could be quantitatively estimated by Winzler´s method and phenolsulfuric acid method, respectively.
In order to confirm the quantitative changes of seromucoid and non-seromucoid in nasal secretion according to natures and degrees of the diseases involving the nasal cavity, the author collected the nasal secretions from the both nasal cavities from 29 control groups (53 samples), 126 patients (201 samples) who visited Dept. of Otolaryngology, College of Medicine, Chung-Ang University. The 126 patients were diagnosed as rhinitis (57 cases), paranasl sinusitis (57 cases) and malignant neoplasm (12 cases) by the clinical points of view; disease history and X-ray finding etc..
The following results were ensued;
1. In the control group, estimated levels of rprotein-bound-carbohydrate in the nasal secretion were 32.9±8.9mg/l00ml and seromucoid were 1105.3±214.4mg/100mI.
2. Estimated levels of seromucoid in the nasal secretion were increased significantly in the group of sinusitis, chronic inflammation, mucopurulent or purulent discharge, hypertrophy or atrophied mucosa, and nasal polyp.
3. Estimated levels of protein-bound-carbohydrate in the nasal secretion were decreased significantly in the group of rhinitis, acute inflammation, serous or mucous discharge, and hyperemic nasal mucosa.
4. In the malignant neoplasm group, estimated levels of seromucoid were decreased and protein-bound-carbohydrate ;were increased than the control group, but those data were not statistically significant.
5. In the group of allergic rhinitis, estimated levels of seromucoid and protein-bound-carbohydrate in the nasal secretions were significantly decreased.
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